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- W2380451834 abstract "Objective:To explore the relationship between norepinephrine (NE),5-hydroxy tryptamine (5-HT),dopamine (DA) and pathogenesis of hypertensive disorder complicating pregnancy (HDCP) by detecting the levels of NE,5-HT and DA in placental tissues of normal pregnant women and women with HDCP.Methods:Immunohistochemical streptomycin and antibiotin-peroxidase method was used to detect NE and DA quantitatively and qualitatively in placental tissues from 31 normal pregnant women of early,middle and late pregnancy (normal pregnancy group),38 women of gestational hypertension,mild preeclampsia and severe preeclampsia.Results:Location:in normal pregnancy group,NE,5-HT and DA located in cell membrane and cytoplasm of cytotrophoblast in early pregnant women and cell membrane and cytoplasm of syncytiotrophoblast and endothelium of capillary vessel in middle and late pregnant women;the locations of NE,5-HT and DA in gestational hypertension group were as well as normal pregnancy group.Quantification:in normal pregnancy group,the level of NE reduced from (1.595 ± 0.018) (early pregnancy group) to (1.488 ± 0.019) (middle pregnancy group),(1.419 ± 0.014) (late pregnancy group) (P 0.01) ;the level of DA reduced from (1.552 ±0.067) (early pregnancy group) to (1.369 ±0.051) (middle pregnancy group),(1.302 ± 0.013) (late pregnancy group) (P 0.01) ;the level of 5-HT increased from (1.497 ± 0.022) (early pregnancy group) to (1.538 ± 0.017) (middle pregnancy group),(1.554 ± 0.013) (late pregnancy group) (P 0.01).In gestational hypertension group,according to degree of hypertension,the levels of DA were (1.378 ± 0.029),(1.305 ± 0.023) and (1.237 ± 0.024) (P 0.01) ;the levels of NE were (1.494 ± 0.018),(1.624 ± 0.014) and (1.917 ± 0.044) (P 0.01) ;the levels of 5-HT were (1.411 ±0.034),(1.374 ±0.017) and (1.324 ±0.014) (P 0.01).Conclusion:In normal pregnancy group,monoamine transmitters locate in villous trophoblast during early pregnancy and syncytiotrophoblast during middle and late pregnancy,the levels of NE and DA decrease with gestational weeks,while the level of 5-HT increases;the locations of NE,5-HT and DA in placental tissues of gestational hypertension group are as well as normal late pregnancy group,the levels of NE and DA increase with gestational weeks,while the level of 5-HT decrease." @default.
- W2380451834 created "2016-06-24" @default.
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- W2380451834 date "2010-01-01" @default.
- W2380451834 modified "2023-09-25" @default.
- W2380451834 title "Related research on monoamine transmitters in placental tissues of normal pregnancy and hypertension during pregnancy" @default.
- W2380451834 hasPublicationYear "2010" @default.
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