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- W2380452215 abstract "Objective To study the four-year outcome in patients with treatment-resistant depression, and its related factors. Methods Patients diagnosed as treatment-resistant depression four years before were followed-up by interview or telephone communication. The questionnaire included items associated with treatment, outcome and course of disease. The updated and the baseline information, including the data of demography, illness course, Hamilton rating scale for depre-ssion (HAMD,17 items) and Hamilton rating scale for anxiety(HAMA), were analysed. Results ①Of all the 51 enrolled cases, 41 completed questionnaire, 6 patients lost, 3 patients changed the diagnosis, and 1 patient died of suicide. There was no significant difference in the baseline evaluation in all enrolled patients. ② Of all the 41 patients with complete follow-up information, 70.7% of them received medical treatment, while the other 29.3% discontinued at least one time due to disease recovery or progression. Eighty-eight point five percent took selective serotonin reuptake inhibitors as their antidepressants; among which 77.1% received combination treatment with benzodiazepine, low-dose antipsychotic or mood stabilizer. ③The rates of complete recovery, mostly remission, small partly improvement and totally no response were 4.9%, 51.2%,17.1% and 26.8%, respectively. Accordingly, 56.0% of the patients were satisfied with their treatment, and 75.5% of them had fluctuated course during the past 4 years. ④ The outcome of patients with treatment-resistant depression was related with clinical characteristics including the total scores of HAMD, the anxiety factor of HAMD, the somatic anxiety factor and psychotic anxiety factor of HAMA. Conclusions Although most patients with treatment-resistant depression are compliant to the medical treatment, the outcome is not satisfactory. The poor outcome might relate with the symptom of anxiety." @default.
- W2380452215 created "2016-06-24" @default.
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- W2380452215 date "2007-01-01" @default.
- W2380452215 modified "2023-09-28" @default.
- W2380452215 title "Outcome investigation of treatment-resistant depression:a four-year follow-up study" @default.
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