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- W2380452230 abstract "Objective To clone and study the polymorphism of interleukin 4 (IL 4) proximal promoter from asthmatic patients. Methods The IL 4 proximal promoter segments were amplified and selected by polymerase chain reaction (PCR) and single strand conformation polymorphism (SSCP) with genomic DNA from ten healthy children and forty patients with dominantly allergic familial history were used as template. The selected PCR segments were cloned into recombinant plasmids pIL 4 Jx2. The PCR inserts were sequenced by dideoxy chain termination method in the end. Results Seven aberrant bands were identified in SSCP analysis from forty asthmatic patients. The sequencing results showed that four variant sites were found within or adjacent to the known IL 4 regulatory element. C→A transversion located at 229 position was just within positive regulatory element Ⅰ (PRE Ⅰ) in one patient. C→T transition adjacent to negative regulatory element Ⅱ ( NRE Ⅱ ) and an extra G adjacent to TATA box were found in two patients. A five bases nucleotide deletion was found near signal transducers and activators of transcription 6 responsive element(STAT 6 RE) in one patient. Conclusion There were polymorphisms of IL 4 proximal promoter from allergic asthmatic patients and these polymorphisms might result in aberrant expression of IL 4 gene and asthma. [" @default.
- W2380452230 created "2016-06-24" @default.
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- W2380452230 date "2002-01-01" @default.
- W2380452230 modified "2023-09-27" @default.
- W2380452230 title "Cloning and polymorphism analysis of IL-4 proximal promoter of asthmatic patients" @default.
- W2380452230 hasPublicationYear "2002" @default.
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