Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380455096> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2380455096 abstract "OBJECTIVE To determine the partition coefficients of memantine hydrochloride(MH) and its prodrug(PMH).METHODS The partition coefficient in trichlormethane/water system was measured using shaking flask method by determining the drug concentrations in two phases.Luna C18 column(phenomenex 150 mm×4.6 mm,5 μm) was used with detection wawelength at 225 nm,and the mobile phase consisted of methane-water-triethylamine(70:30:0.5,adjust to pH7.0 with phosphoric acid).The flow rate was 1.0 ml·min-1.RESULTS The partition coefficients of MH and PMH were 2.09 and 227.05,respectively.CONCLUSION The partition coefficient of PMH is higger than that of MH which proves PMH shows higher liposolubility than MH,and implies that the infiltration ability of MH across BBB is increased in the form of PMH." @default.
- W2380455096 created "2016-06-24" @default.
- W2380455096 creator A5012937416 @default.
- W2380455096 date "2009-01-01" @default.
- W2380455096 modified "2023-09-26" @default.
- W2380455096 title "Determination of partition coefficients of memantine hydrochloride and its prodrug PMH" @default.
- W2380455096 hasPublicationYear "2009" @default.
- W2380455096 type Work @default.
- W2380455096 sameAs 2380455096 @default.
- W2380455096 citedByCount "0" @default.
- W2380455096 crossrefType "journal-article" @default.
- W2380455096 hasAuthorship W2380455096A5012937416 @default.
- W2380455096 hasConcept C108215921 @default.
- W2380455096 hasConcept C178790620 @default.
- W2380455096 hasConcept C185592680 @default.
- W2380455096 hasConcept C192552737 @default.
- W2380455096 hasConcept C2776460385 @default.
- W2380455096 hasConcept C2781283055 @default.
- W2380455096 hasConcept C43617362 @default.
- W2380455096 hasConcept C55493867 @default.
- W2380455096 hasConceptScore W2380455096C108215921 @default.
- W2380455096 hasConceptScore W2380455096C178790620 @default.
- W2380455096 hasConceptScore W2380455096C185592680 @default.
- W2380455096 hasConceptScore W2380455096C192552737 @default.
- W2380455096 hasConceptScore W2380455096C2776460385 @default.
- W2380455096 hasConceptScore W2380455096C2781283055 @default.
- W2380455096 hasConceptScore W2380455096C43617362 @default.
- W2380455096 hasConceptScore W2380455096C55493867 @default.
- W2380455096 hasLocation W23804550961 @default.
- W2380455096 hasOpenAccess W2380455096 @default.
- W2380455096 hasPrimaryLocation W23804550961 @default.
- W2380455096 hasRelatedWork W2004325277 @default.
- W2380455096 hasRelatedWork W2033135742 @default.
- W2380455096 hasRelatedWork W2117190327 @default.
- W2380455096 hasRelatedWork W2170939581 @default.
- W2380455096 hasRelatedWork W2317373531 @default.
- W2380455096 hasRelatedWork W2341479628 @default.
- W2380455096 hasRelatedWork W2529297215 @default.
- W2380455096 hasRelatedWork W2560604780 @default.
- W2380455096 hasRelatedWork W2766743077 @default.
- W2380455096 hasRelatedWork W2792378996 @default.
- W2380455096 hasRelatedWork W2912029083 @default.
- W2380455096 hasRelatedWork W2184441036 @default.
- W2380455096 hasRelatedWork W2184568453 @default.
- W2380455096 hasRelatedWork W2184874675 @default.
- W2380455096 hasRelatedWork W2186315665 @default.
- W2380455096 hasRelatedWork W2187169381 @default.
- W2380455096 hasRelatedWork W2189341002 @default.
- W2380455096 hasRelatedWork W2510410364 @default.
- W2380455096 hasRelatedWork W2514510886 @default.
- W2380455096 hasRelatedWork W2524361061 @default.
- W2380455096 isParatext "false" @default.
- W2380455096 isRetracted "false" @default.
- W2380455096 magId "2380455096" @default.
- W2380455096 workType "article" @default.