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- W2380455768 abstract "Objective To study the effect of heavy drinking on angiogenesis in ischemic rats and the effect of Rosuvastatin on angiogenesis after heavy drinking. Methods A total of 24 male SD rats w ere randomly divided into 3 groups: control group,heavy-drinking group[50% ethanol,5 g /( kg·d) ]and Rosuvastatin pretreated group[Rosuvastatin( 20 mg /( kg·d) + 50% ethanol,5 g /( kg·d) ]. The three groups w ere given equal volume of ethanol,rosuvastatin and vehicle by gavage respectively for 4 w eeks and then myocardial infarction models w ere constructed. The rats w ere killed on the 3rd day after myocardial infarction. The microvascular density( MVD) w as observed by immunohistochemical SP method. The vascular endothelial grow th factor( VEGF) and endostatin expressions in the ischemia myocardium tissue w ere tested w ith ELISA. Results Compared to the control group,the MVD w as significantly reduced( P 0. 01) in the heavy-drinking group,the level of endostatin w as significantly increased( P 0. 01),and there w as no difference in the expression of VEGF. MVD in the Rosuvastatin pretreated group w as significantly increased compared to that in the heavy-drinking group( P 0. 01),but the VEGF and endostatin expressions w ere not significantly different betw een the tw o groups( P 0. 05). Conclusion Heavy drinking could inhabit angiogenesis by increasing the expression of endostatin after myocardial infarction. Rosuvastatin could reverse the damages of heavy drinking on angiogenesis." @default.
- W2380455768 created "2016-06-24" @default.
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- W2380455768 date "2014-01-01" @default.
- W2380455768 modified "2023-09-23" @default.
- W2380455768 title "Rosuvastatin reverses the effect of heavy drinking on angiogenesis after infarction in rats" @default.
- W2380455768 hasPublicationYear "2014" @default.
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