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- W2380455884 abstract "Objective To investigate the therapeutical effect and mechanism of Fei Tong oral liquid on the acute lung injury in rats.Methods Forty SD rats were randomly divided into model group,treatment group,hormone group and normal control group group with 10 in each,model of pulmonary fibrosis were established in the former 3 groups by using BLEMA5.Then the treatment group was given Fei Tong oral liquid(250 mg/kg) by gavage,the hormone group was given hydrocortisone(25 mg/kg) intramuscular injection;The control group was given disposable tracheal instillation of 0.9% saline solution(2 mL/kg).HE,VG staining were used to observe the pathological changes of cell,ELISA method was used to determine the neutrophil elastase(NE) contents.Results Compared with the normal control group,the alveolitis and pulmonary fibrosis of model group was heavy,and the deposition of collagen was more,the content of serum NE increased significantly(P0.01);The alveolitis and fibrosis of treatment group lessen,the deposition of collagen was significantly reduced,the content of serum NE was significantly lower than that in the model group and treatment group(P0.01).Conclusion Fei Tong oral liquid can significantly reduce the alveolitis and pulmonary fibrosis of rats with acute lung injury,the mechanism maybe related to decrease the pulmonary capillary permeability and edema by down-regulating the level of NE." @default.
- W2380455884 created "2016-06-24" @default.
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- W2380455884 date "2013-01-01" @default.
- W2380455884 modified "2023-09-28" @default.
- W2380455884 title "Therapeutical effect and mechanism of Fei Tong oral liquid on the acute lung injury in rats" @default.
- W2380455884 hasPublicationYear "2013" @default.
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