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- W2380456321 abstract "To explore the effects of TNF-α on NF-κB activation in fibroblast-like synoviocytes(FLS) of RA.Firstly,RA FLS were primarily cultured.Western blot was applied to examine the expression of p65-NF-κB protein and IκBα degradation in RA FLS stimulated with different periods of TNF-α.Immunofluorescence was applied to study NF-κB p65 nuclear translocation induced by TNF-α.The results showed that TNF-α increased the expression and nuclear translocation of NF-κB p65.TNF-α also promoted the IκBα degradation in RA FLS.This study suggest that TNF-α can induce NF-κB activation in RA FLS,which involves in the course and development of RA inflammation." @default.
- W2380456321 created "2016-06-24" @default.
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- W2380456321 date "2012-01-01" @default.
- W2380456321 modified "2023-09-23" @default.
- W2380456321 title "Activation of NF-κB signal pathway by TNF-α in synoviocytes of rheumatoid arthritis" @default.
- W2380456321 hasPublicationYear "2012" @default.
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