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- W2380456460 abstract "Objective To investigate the effect of pioglitazone on the hypoxia-reoxygenation induced cardiac myocytes apoptosis and the expression of HIF-1α.Methods Cultured cardiomyocytes of neonatal Sprague-Dawley rats were divided into four groups:vehicle,hypoxia/reoxygenation + vehicle,hypoxia/reoxygenation + pioglitazone 0.1μM,hypoxia/reoxygenation + pioglitazone 1μM.We measured the apoptosis rate of cardiomyocytes after hypoxia/reoxygenation.RT-PCR and Western blot analysis were performed to detect expressions of HIF-1α mRNA and protein expression.Results Apoptosis index in hypoxia/reoxygenation + vehicle group significantly increased than in the vehicle group.Pioglitazone decreased apoptosis index in dose-dependent manner(P0.05).Hypoxia/reoxygenation induced upregulation of HIF-1α both in mRNA and protein level.Pioglitazone further increased the expression of HIF-1α(P0.05).Conclusion Pioglitazone can protect the cardiomyocyte from I/R injury by reducing cardiomyocyte apoptosis.The protective effect is likely to occur by regulation of HIF-1α expression." @default.
- W2380456460 created "2016-06-24" @default.
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- W2380456460 date "2009-01-01" @default.
- W2380456460 modified "2023-09-26" @default.
- W2380456460 title "The Effect of Pioglitazone on the Hypoxia-reoxygenation Induced Cardiac Myocytes Apoptosis and the Expression of HIF-1α" @default.
- W2380456460 hasPublicationYear "2009" @default.
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