Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380456664> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2380456664 abstract "Five pyridine-bearing endothelin receptor antagonists based on ambrisentan as structural template were designed and synthesized.The synthetic procedure started from benzophenone,which underwent Darzens condensation to afford an epoxide.The epoxide was opened when treated with p-toluenesulfonic acid in refluxing methanol to give methyl 3,3-diphenyl-2-hydroxy-3-methoxypropionate,which was saponified to yield the corresponding acid followed by revolution with(S)-1-(p-chlorophenyl) ethylamine to furnish the enantiomerically pure(S)-3,3-diphenyl-2-hydroxy-3-methoxypropionic acid in the form of an aminium salt.Coupling of the aminium salt of this enantiomerically pure hydroxyl carboxylic acid and the pyridine-bearing electrophiles in the presence of lithium amide furnished the desired title compounds,(S)-3,3-diphenyl-3-methoxy-2-(substituted pyridinyloxy)propionic acids.Biological activity evaluated with rat aortic ring relaxation model revealed that the potency order of endothelin receptor antagonism was 9b9a10b9c10a,indicating that more substituents at m-positions more potent were their endothelin receptor antagonism." @default.
- W2380456664 created "2016-06-24" @default.
- W2380456664 creator A5029323907 @default.
- W2380456664 date "2011-01-01" @default.
- W2380456664 modified "2023-09-27" @default.
- W2380456664 title "Design,synthesis and biological activity of pyridine-bearing diphenylpropionic acid derivatives" @default.
- W2380456664 hasPublicationYear "2011" @default.
- W2380456664 type Work @default.
- W2380456664 sameAs 2380456664 @default.
- W2380456664 citedByCount "0" @default.
- W2380456664 crossrefType "journal-article" @default.
- W2380456664 hasAuthorship W2380456664A5029323907 @default.
- W2380456664 hasConcept C155647269 @default.
- W2380456664 hasConcept C15761196 @default.
- W2380456664 hasConcept C161790260 @default.
- W2380456664 hasConcept C170493617 @default.
- W2380456664 hasConcept C178790620 @default.
- W2380456664 hasConcept C185592680 @default.
- W2380456664 hasConcept C2776920199 @default.
- W2380456664 hasConcept C2777383412 @default.
- W2380456664 hasConcept C2778439535 @default.
- W2380456664 hasConcept C2779485729 @default.
- W2380456664 hasConcept C50027330 @default.
- W2380456664 hasConcept C55493867 @default.
- W2380456664 hasConcept C71240020 @default.
- W2380456664 hasConceptScore W2380456664C155647269 @default.
- W2380456664 hasConceptScore W2380456664C15761196 @default.
- W2380456664 hasConceptScore W2380456664C161790260 @default.
- W2380456664 hasConceptScore W2380456664C170493617 @default.
- W2380456664 hasConceptScore W2380456664C178790620 @default.
- W2380456664 hasConceptScore W2380456664C185592680 @default.
- W2380456664 hasConceptScore W2380456664C2776920199 @default.
- W2380456664 hasConceptScore W2380456664C2777383412 @default.
- W2380456664 hasConceptScore W2380456664C2778439535 @default.
- W2380456664 hasConceptScore W2380456664C2779485729 @default.
- W2380456664 hasConceptScore W2380456664C50027330 @default.
- W2380456664 hasConceptScore W2380456664C55493867 @default.
- W2380456664 hasConceptScore W2380456664C71240020 @default.
- W2380456664 hasLocation W23804566641 @default.
- W2380456664 hasOpenAccess W2380456664 @default.
- W2380456664 hasPrimaryLocation W23804566641 @default.
- W2380456664 hasRelatedWork W1990738830 @default.
- W2380456664 hasRelatedWork W1999650553 @default.
- W2380456664 hasRelatedWork W2009006419 @default.
- W2380456664 hasRelatedWork W2034180556 @default.
- W2380456664 hasRelatedWork W2068179576 @default.
- W2380456664 hasRelatedWork W2070932390 @default.
- W2380456664 hasRelatedWork W2088603842 @default.
- W2380456664 hasRelatedWork W2115458642 @default.
- W2380456664 hasRelatedWork W2125484484 @default.
- W2380456664 hasRelatedWork W2127647075 @default.
- W2380456664 hasRelatedWork W2149892859 @default.
- W2380456664 hasRelatedWork W2150155317 @default.
- W2380456664 hasRelatedWork W2318077010 @default.
- W2380456664 hasRelatedWork W2363876130 @default.
- W2380456664 hasRelatedWork W2885267679 @default.
- W2380456664 hasRelatedWork W2949767152 @default.
- W2380456664 hasRelatedWork W2950064856 @default.
- W2380456664 hasRelatedWork W2950147125 @default.
- W2380456664 hasRelatedWork W2094603552 @default.
- W2380456664 hasRelatedWork W2770938943 @default.
- W2380456664 isParatext "false" @default.
- W2380456664 isRetracted "false" @default.
- W2380456664 magId "2380456664" @default.
- W2380456664 workType "article" @default.