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- W2380457526 abstract "Objective:To explore therapeutic effects of magnesium sulfate(MgSO 4) during cerebral ischemia-reperfusion.Methods:Using an intraluminal thread method,a cerebral ischemia-model(Middle Cerebral Artery Occlusion,MCAO)of rat was developed.To observe the cerebral Na +-K +-ATPase activity changes,nitricoxide(NO)levels and contents of water in brain at 3 hours reperfusion following 2 hours cerebral ischemia,40 Sprague-Dawley(SD)rats were randomly divided into sham-operated group(10 rats),control group(15 rats)and treatment group(15 rats),and MgSO 4(500 mg/kg)was administered in treatment group at the beginning of reperfusion.Results:The cerebral Na +-K +-ATPase activity decreased(P0 01),and NO levels and contents of water in brain increased significantly (P0 01)in the control group,compared with sham-operated group.The cerebral Na +-K +-ATPase activity increased(P0 01),NO levels and contents of water in brain decreased(P0 01)significantly in the treatment group compared with control group.Conclusion:MgSO 4 administered may prevent brain injury from cerebral ischemia-reperfusion." @default.
- W2380457526 created "2016-06-24" @default.
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- W2380457526 date "2001-01-01" @default.
- W2380457526 modified "2023-09-23" @default.
- W2380457526 title "The preventive effects of MgSO_4 during cerebral ischemia-reperfusion" @default.
- W2380457526 hasPublicationYear "2001" @default.
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