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- W2380459067 abstract "The cytotoxin of Helicobacter pylori( Hp) plays an important role in the initiation and development of gastric cancer. Both the cytotoxin-associated gene pathogenicity island( CagPAI) and the vacuolating cytotoxin A( vacA) are the most typical virulence factors in Hp. CagPAI which may induce the release of pro-inflammatory factors overly promote epithelial cell's proliferation and mobility,even show a hummingbird phenotype. CagPAI is also related to the abnormal mitosis and the destructure of apical junctional complex. While vacA seriously damages human gastric epithelial cells by vacuolization mechanism. Clarifying the effect of the above virulence factors is required for understanding the pathogenesis of Hp-related gastric cancer. Here we will, based on the knowledge of the molecular structure,biochemical properties,signaling pathway and biological genetic in the bacteria and the host,give a brief elaboration of the Hp cytotoxin related gastric cancer." @default.
- W2380459067 created "2016-06-24" @default.
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- W2380459067 date "2014-01-01" @default.
- W2380459067 modified "2023-09-27" @default.
- W2380459067 title "Effect of Helicobacter pylori virulence factors on gastric cancer" @default.
- W2380459067 hasPublicationYear "2014" @default.
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