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- W2380460766 abstract "Objective This study was undertaken to investigate the effect of Roxithromycin on treatment in mild asthma with smoking. Methods 36 mild smoking patients with asthma were divided into group A and group B randomly. Group B treated with inhaled Beclomethasone dipronionate Syray 500 μg/d and inhaled Ventolin when it was needed for 4 weeks. Group A treated with oral Roxithromycin dispersible tablet 0.15 g/d and other treatment as well as group B for 4 weeks. The lung function tests, airway hyperreactivity and counting cellar in induced sputum of all patients were made before treatment and after treatment. Results There was no significantly improvement in morning PEF (peak expiratory flow), forced expiratory volume in 1 second (FEV1% ), airway hyperreactivity and the neutrophil in induced sputum in group B(P0.05). There was significantly greatly improvement in morning PEF, FEV1%, and airway hyperreactivity in group A(P0.01).And the neutrophil in induced sputum had been reduced in group A(P0.01). There was negative correlation between neutrophil in induced sputum and morning PEF, FEV1%(P0.01). Otherwise there was positive correlation between neutrophil in induced sputum and airway hyperreactivity(P0.01). Conclusion In mild asthma with smoking, there was negative correlation between neutrophil in induced sputum and morning PEF, FEV1%. Otherwise there was positive correlation between neutrophil in induced sputum and airway hyperreactivity. Roxithromycin can reduce neutrophil in induced sputum and facilitate beclomethasone dipronionate syray and ventolin to improve morning PEF, forced expiratory volume in 1 second (FEV1% ), airway hyperreactivity of mild asthma with smoking." @default.
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- W2380460766 date "2007-01-01" @default.
- W2380460766 modified "2023-09-25" @default.
- W2380460766 title "Influence of small dose roxithromycin on treatment in mild asthma patients with smoking" @default.
- W2380460766 hasPublicationYear "2007" @default.
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