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- W2380463777 abstract "The differential expression of mRNA between RF-1 cell line (primary tumor of gastric adenocarcinoma patient) and RF-48 cell line (its metastatic counterpart) was cloned by fluorescent differential display-PCR(FDD-PCR).45 differential fragments were finally obtained. Comparison of expression of mRNA between RF-1 and RF-48 cells enabled us to identify 38 genes, including 3 novel genes, that were highly up-regulated, and 7 genes that were apparently down-regulated. One gene named wcl1, highly up-regulated in RF-48 cells, was cloned and identified using bio-informatics techniques. Full-length of approximately 664 bp wcl1 cDNA containing a largest opening-reading frame of 240 bp was obtained, which located at human chromosome 11q14. The stretched result from electron-clone by internet was confirmed by RT-PCR and Northern-blot(Accession Number AF364863). wcl1 encodes a polypeptide containing 79 amino acid residues with a predicted pI/M r of 5.28/8 961.72, located to cytoplasm. Analyzing its amino acid sequence, it was found that Wcl1 contained a unknown functional region similar to UPF0016 protein and a leucine zipper motif at amino acids 57-78, no highly homologous with known protein. Compared to brain polocytic astrocytoma, invasive breast ductal tumor and the normal gastric tissue, wcl1 mRNA expression is apparently increased in microvascular endothelial cells and the poorly differential gastric cancer, respectively. These data indicated that Wcl1 might involve in gene transcription and regulation during gastric adenocarcinoma metastasis process." @default.
- W2380463777 created "2016-06-24" @default.
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- W2380463777 date "2002-01-01" @default.
- W2380463777 modified "2023-09-26" @default.
- W2380463777 title "Cloning of a Novel Gastric Adenocarcinoma Metastasis Related Gene wcl1 by Fluorescent Differential Display-PCR" @default.
- W2380463777 hasPublicationYear "2002" @default.
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