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- W2380477659 abstract "Objective: To study the hypermethylation of DAPKⅠand RARβ in cervical cancer and their association with high-risk type HPV infection.Methods: We collected exfoliated cells from 48 patients of chronic cervicitis、14 patients of CINⅠ/CINⅡ、14 patients of CINⅢ,28 patients of invasive cervical cancer.All specimens were performed with MSP and HPV type-differentia detection.Results: When classified the patients into groups of cervitis,CINⅠ/CINⅡ,CINⅢ and ICC,we found the hypermethylation rates of DAPKⅠ were 2.08%,14.28%,50.00% and 60.71%.And to RARβ,the rates were 4.55%,7.69%,42.86% and 53.57%.And to the infection of the high-risk type HPV,the rates were 33.33%,50%,71.43% and 89.29%.The relation coefficient of hypermethylation of the two genes compared respectively with the infection rates of high-risk type HPV were 0.48 and 0.46.Conclution: The hypermethylation of DAPKⅠand RARβ is an early event in cervical cancer,and it has a positive correlation with the high-risk type HPV infection." @default.
- W2380477659 created "2016-06-24" @default.
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- W2380477659 date "2011-01-01" @default.
- W2380477659 modified "2023-09-23" @default.
- W2380477659 title "Role of hypermethylation of DAPKIand RARβ in cervical cancer and their association with high-risk type HPV infection" @default.
- W2380477659 hasPublicationYear "2011" @default.
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