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- W2380490747 abstract "AIM To investigate the change of activity of the nitric oxide synthase (NOS) in the kidney of spontaneously hypertensive rats and the role in the mechanism of hypertension. METHODS Activity of NOS was assayed by monitoring the convertion of 3H arginine to 3H citruline. RESULTS The activity of neural type of NOS (nNOS) in the kidney protein of spontaneously hypertensive rats (SHR) was much lower than that in Wistar Kyoto (WKY)(activity of nNOS: (21.9±7.4) kBq·g -1 and (43.2±9.3) kBq·g -1 for SHR and WKY,respectively( P 0.05). After the stimulation by the acetylcholine(Ach)1, activity of endothelia type of NOS (eNOS) in SHR was also lower than that in WKY(activity of eNOS: (67.3±14.6) kBq·g -1 and (8.57±23.8) kBq·g -1 for SHR and WKY, respectively( P 0.05). CONCLUSION The insufficient activity of nNOS and eNOS could play important role in the genesis and development of hypertension." @default.
- W2380490747 created "2016-06-24" @default.
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- W2380490747 date "2000-01-01" @default.
- W2380490747 modified "2023-09-24" @default.
- W2380490747 title "Nitric oxide synthase activity in kidney of spontaneously hypertensive rats" @default.
- W2380490747 hasPublicationYear "2000" @default.
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