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- W2380491157 abstract "Objective:Non small cell lung cancer (NSCLC) frequently expresses high levels of epidermal growth factor receptor (EGFR). EGFR monoclonal antibody (McAb) Egf/r3 has potential activity against human lung adenocarcinoma cell lines. The aim of this work is to investigate whether Egf/r3 McAb has a capacity to inhibit the cell cycle progression of human lung adenocarcinoma and the potential usefulness of combining with cisplatin(CDDP) and 8-Mop, a Chinese herb.Methods:Using EGFR overexpressing lung adenocarcinoma cell lines SPC-A-1 and A549 as targets, potential cooperation of Egf/r3 and chemotherapy or Chinese herb was studied by MTT assay.Results:Treatment with Egf/r3 McAb for 72h induced accumulation of SPC-A-1 and A549 cells in G_1-phase with 5.0% and 7.8% separately, decreased in the percentage of cells in S-phase relative to controls, no significant changes in the percentage of cells within G_2-M phase were observed in this experiment. The antitumor activity of these drugs were great enchanced while Egf/r3 McAb was combined with CDDP or 8-Mop, the cellular cytotoxicity reached at least two times of Egf/r3 McAb, CDDP and 8-Mop separately.Conclusion:Egf/r3 McAb induces G_1 cell cycle arrest, makes target cell in a pace foot, which may increase target cell sensitivity to chemotherapy or inhibit repair after chemotherapy, this might result in a synergistic antitumor effect of Egf/r3 McAb with cisplatin(CDDP) and 8-Mop." @default.
- W2380491157 created "2016-06-24" @default.
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- W2380491157 date "2006-01-01" @default.
- W2380491157 modified "2023-09-23" @default.
- W2380491157 title "Effects of Egf/r3 mcAb against human lung adenocarcinoma cell lines in vitro" @default.
- W2380491157 hasPublicationYear "2006" @default.
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