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- W2380492365 abstract "Objective To screen differentially expressed kallikrens in gastric cancer(GC) and assess the relationship between the expressing profiles of these genes with the patients′ clinical features and prognosis.Methods The differentially expressed kallikrens genes screened by cDNA microarrays were confirmed by real-time PCR in 10 pairs of cancerous and 10 pairs of noncancerous gastric tissues.The expressing profiles of these confirmed genes in GC were assayed by immunohistochemistry method,and the relationship between the expressing profiles with the patients′ clinical features and prognosis were assessed.Results KLK10 was up-regulated by 9.55 folds in GC,and KLK11 was down-regulated by 12.02 folds.The expressing profile of the KLK10 in GC was significantly associated with the tumor size,depth of tumor invasion and lymph node metastasis,while that of the KLK11 was not.Depth of tumor invasion,lymph node metastasis,and the expressing profiles of the KLK10 and KLK11 were all significantly associated with the patients′ overall survival.Conclusions KLK10 and KLK11 were differentially expressed in GC.The expressing profile of the KLK10 is significantly associated with the tumor size,depth of tumor invasion,lymph node metastasis and the patients′ overall survival,while that of the KLK11 is significantly associated with the patients′ overall survival only." @default.
- W2380492365 created "2016-06-24" @default.
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- W2380492365 date "2011-01-01" @default.
- W2380492365 modified "2023-09-27" @default.
- W2380492365 title "Screening differentially expressed kallikrens in gastric cancer and its clinical significance" @default.
- W2380492365 hasPublicationYear "2011" @default.
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