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- W2380492615 abstract "Objective: Hepatocellular carcinoma(HCC) is a highly malignant tumor,we put forward new data reported about small HCC in order to screen potential biomarker for diagnosis of early-HCC.Methods: Ten pairs of tissues from HBV-infected small HCC patients were collected and treated with protein extraction.The extracted proteins were well resolved by two-dimensional electrophoresis(2-DE),and these HCC-associated proteins were identified by MALDI-TOF/TOF MS following image analysis.Results: 15 up-regulated and 3 down-regulated unique proteins were identified.Oxidoreductase and 3 of 5 metabolism associated proteins were increased,whereas 2 of 5 metabolism associated proteins were decreased in HCC samples.Finally,the overexpression of carbonyl reductase 1(CBR1) and heat shock protein 27(HSP27) in HCC tissues was confirmed by Real-time PCR and then by Western blotting in 10 HCC samples.Conclusion: CBR1 and HSP27 may be potential marker for early-HCC." @default.
- W2380492615 created "2016-06-24" @default.
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- W2380492615 date "2011-01-01" @default.
- W2380492615 modified "2023-09-26" @default.
- W2380492615 title "Carbonyl reductase 1 and heat shock protein 27 may be potential marker for early-hepatocellular carcinoma" @default.
- W2380492615 hasPublicationYear "2011" @default.
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