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- W2380492666 abstract "Objective:To investigate the effects of swimming training on endothelium-dependent vasodilation function of aorta in diabetic rats and to explore it's possible mechanism.Method:Forty male SD rats were assigned into normal control group(CG), diabetic control group(DCG) and diabetic swimming group(DSG). After 8 weeks swimming, aortic rings were isolated for recording vascular tension in vitro; end othelium-dependent dilation induced by acetylcholine(ACh) and endothelium-independent dilation induced by sodium nitroprusside(SNP) were measured. The serum NO levels were determined by Griess reaction. The serum glucose, insulin, total cholesterol(TC), triglycerides(TGs), malondialdehyde(MDA),glutathione peroxidase(GSH-Px), superoxide-dismutase(SOD) were detected.Result: In diabetic group endothelium-dependent vasodilation reaction of aorta induced by Ach was significantly weakened(P0.05). In diabetic swimming group endothelium-dependent vasodiation reaction of aorta could be amelibrated significantly. However, the endothelium-independent vasodilation reactions induced by SNP were not significantly different in aorta of all groups(P0.05). The NO levels of diabetic group were significantly lower(P0.05), In diabetic swimming group NO levels improved significantly(P0.05). Compared with diabetic group, in-diabetic swimming group glycaemia and insulin showed amelioration, accompanied by remarkable reduction of oxidative stress.Conclusion: Swimming can improve the aortic endothelium- dependent vasodilation reaction in diabetic rats,which involved the improvement of hyperglycemia, the reduction of oxidative stress, and increasing NO bioavailability." @default.
- W2380492666 created "2016-06-24" @default.
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- W2380492666 date "2014-01-01" @default.
- W2380492666 modified "2023-09-25" @default.
- W2380492666 title "Effects of swimming training on endothelium-dependent vasodilation function of aorta in diabetic rats and its mechanisms" @default.
- W2380492666 hasPublicationYear "2014" @default.
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