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- W2380493398 abstract "Objective To study the effect of propofol on oxidative stress induced retinal cells injury in vitro.Methods Mouse retinal cells were primary cultured;and were treated by propofol with different concentrations following by H2O2treatment.The cell viability and proliferation were measured with MTS assay,and the reactive oxygen species(ROS)was detected by means of flow cytometry analysis,The changes of malondialdehyde(MDA),superoxide dismutase(SOD), glutathione peroxidase(GSH-Px),glutathione-s-transferase(GST),myeloperoxidase(MPO),NF- κB,IL-6,and IL-1βwere measured.Results Cell survival rate were 33.5%,65.2% and 85.5% by 0,5and 50μg/ml propofol treatment;ROS production were 1007.8%,398.9%and 256.2%,MDA expression were 301.5%,221.4%and 172.4%,SOD level were 28.5%,44.2%and 71.3%,GST level were 32.6%,52.1%and 66.8%,GSH-Px level were 25.8%,65.2%and 76.5%,MPO level were 285.2%,236.6%and 166.3%;NF-κB expression were 933.3%,576.9%and 472.2%;IL-1β level were 346.4%,292.6% and 180.0%;IL-6level were 224.6%,187.9% and 148.0%;when compared with control group(P 0.05).Conclusion Propofol may reduce the H2O2-induced oxidative stress injury of primary retinal cells,by increasing the production of antioxidant enzymes, and inhibiting the activation of NF-κB and the generation of inflammatory factors." @default.
- W2380493398 created "2016-06-24" @default.
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- W2380493398 date "2013-01-01" @default.
- W2380493398 modified "2023-09-23" @default.
- W2380493398 title "Effects of propofol on oxidative stress and retinal cells injury in vitro" @default.
- W2380493398 hasPublicationYear "2013" @default.
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