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- W2380493424 abstract "Objective:To observe the changes of expression of IGF-I and GAP-43 mRNA in rat dorsal root ganglion of early diabetes and effect of insulin treatment on them.Methods:Insulin-dependent diabetes mellitus model were induced with a single intraperitoneal injection of streptozotocin(STZ,60mg/kg) .After model was made successfully,the diabetic model rats were divided into two groups(the diabetic model group and the insulin treatment group) .In the second day,the insulin treatment group was injected subcutaneously with protamine zinc insulin once a day.The administration was ceased on the end of the second week,then the dorsal root ganglion of rats in each group were isolated and the total RNA was extracted by using Trizol reagent and the IGF-I and GAP-43 gene expression were detected by the method of RT-PCR.Results:The levels of IGF-I and GAP-43 mRNA were decreased obviously in early diabetic DRG(P0.01) ,and insulin treatment could up-regulate the gene expression of IGF-I significantly(P0.01) and had the tendency of increasing GAP-43 expression.Conclusion:The reductions of IGF-I and GAP-43 mRNA in DRG of early phase of diabetes may contribute to the pathogenesis of diabetic peripheral neuropathy." @default.
- W2380493424 created "2016-06-24" @default.
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- W2380493424 date "2007-01-01" @default.
- W2380493424 modified "2023-09-24" @default.
- W2380493424 title "Expression of IGF-I and GAP-43 mRNA in rat dorsal root ganglion of early diabetes" @default.
- W2380493424 hasPublicationYear "2007" @default.
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