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- W2380493695 abstract "Objective:To research the mechanism of Stilbene Glucoside from Polygonum multiflovum Thumb on hyperlipemia.Methods:Bel-7402 cells were grown in 1640 medium with 10% FBS for 24hrs.The medium was replaced with serum-free medium and cells were incubated for another 24 hrs.1 umol/L、10 umol/L、100 umol/L tsg and 10 umol/L atorvastatin were added in medium.Gene expression of LDLR,HMGCOAR, CYP7A1and ACAT were measured.Results:compared with the control group,The expression of LDLR,HMGCOAR were increased significantly by each dose of TSG(P0.05,P0.01).ACAT mRNA expression were reduced by Atorvastatin(P0.05),TSG did not have effect on the expression of ACATcell(P0.05),both TSG and Atorvastatin did not have effect on the expression of Cyp7a1.Conclusions:TSG inhibite cholesterol synthesis in cell,elevate the expression of low-density lipoprotein receptor,and this may be the mechanism of hypolipidemic by TSG." @default.
- W2380493695 created "2016-06-24" @default.
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- W2380493695 date "2008-01-01" @default.
- W2380493695 modified "2023-09-25" @default.
- W2380493695 title "Mechanism Research of Stilbene Glucoside from Polygonum Multiflovum Thunb on Hyperlipemia" @default.
- W2380493695 hasPublicationYear "2008" @default.
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