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- W2380493939 abstract "Objective To investigate the association between catechol-O-methyhransferase (COMT) gene polymorphism and both of schizophrenia onset risk and clinical feature.Methods Case control study was used and a total of 83 Chinese Han schizophrenic patients and 65 healthy comparison subjects were recruited in this study. All patients were examined by trained psychiatrists using the Chinese Classification of Mental Disorders (CCMD-3) criteria. The psychiatric symptom was evaluated by using the positive and negative syndrome scale (PANSS). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for COMT genotypes determined. Results The difference of genetic influences between schizophrenia patients and health control in the COMT Val158Met genotype distributions was obtained (P=0.038). The Val allele in patients was obviously higher than that in control in genotype frequencies analysis (P=0.008). In addition, the COMT polymorphism was relative to age and disease course. Conclusions COMT polymorphism may be a susceptive factor for the development of schizophrenia and is relative to age and disease course of schizophrenia." @default.
- W2380493939 created "2016-06-24" @default.
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- W2380493939 date "2012-01-01" @default.
- W2380493939 modified "2023-09-26" @default.
- W2380493939 title "COMT polymorphism in schizophrenia onset risk and its correlation with clinical features" @default.
- W2380493939 hasPublicationYear "2012" @default.
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