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- W2380497413 abstract "Receptor tyrosine kinases (RTKs) have been shown to play a crucial role in the cellular signal transduction pathways. The overexpress of RTKs caused cellular proliferation have close relationship with malignant tumor development. A novel molecule family selectively inhibit HER2 receptor, one of the PTKs, were found recently. Flexible pharmacophore research was performed on this group of tyrophostins in this study. A common pharmacophore model was generated and regressed within the ensemble of 19 active compounds. The pharmacophore model shows great correlate coefficient (R = 0 958) and high forcast ability. The model proved to correctly represent the 3D factors affect the tyrphostins' biological activity." @default.
- W2380497413 created "2016-06-24" @default.
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- W2380497413 date "2000-01-01" @default.
- W2380497413 modified "2023-09-23" @default.
- W2380497413 title "Pharmacophore Model Analysis of Novel Tyrphostins" @default.
- W2380497413 hasPublicationYear "2000" @default.
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