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- W2380497645 abstract "OBJECTIVE:To investigate the differentiation-inducing effect of Luffaculin-1 on B16 mouse melanoma cells. METHODS: Evaluate the inhibitory effect of Luffaculin-1 on proliferation of B16 cells by MTT assay. Estimate the differentiation-inducing activity of Luffaculin-1 in B16 cells, by observations on morphology, melanin content and distribution of cell cycle. RESULTS: Luffaculin-1 significantly inhibited the proliferation of B16 cells in dose- and time-dependent manners, and IC_(50) of 48 and 72 h were 33.29 and 10.28 g/L,respectively. Luffaculin-1 interrupted the transition of cell cycle from G_1 phase to S phase, and arrested at the G_1 phase of cell cycle. With Luffaculin-1 treatment, B16 cells were induced to differentiate into mature epithelia-like cells, grew slowly in monolayer and even formed reticulation. Luffaculin-1 also enriched cell organelles in cytoplasm, and melanosomes of different stages (Ⅰ- Ⅳ) can be observed. Meanwhile the content of melanin enhanced markedly. Compared with control, melanin contents in 2.5, 5, 10 and 20 mg/L of Luffaculin-1 treated groups were 2.1, 4.4, 5.9 and 7.8 times, respectively. CONCLUSION: Luffaculin-1 can significaotly induce differentiation of B16 cells." @default.
- W2380497645 created "2016-06-24" @default.
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- W2380497645 date "2005-01-01" @default.
- W2380497645 modified "2023-09-25" @default.
- W2380497645 title "Differentiation-inducing effect of Luffaculin-1 on B16 melanoma cells" @default.
- W2380497645 hasPublicationYear "2005" @default.
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