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- W2380521643 abstract "Objective The purpose of this study was to establish an animal model of free muscle transfer with nerve anastomosis using rat gracilis muscle and evaluate some related indexes for muscle atrophy.Methods The gracilis muscle was orthotopic transferred in adult rat to establish the animal model.According the different time after free muscle transfer,muscle weight was measured and compared to that of the control side which had no operation,so did the transaction areas of muscular fiber using NIH Image J software following HE staining.Then muscular function including maximum strength of single contraction and tetanus was recorded using a multiple function physiological recording device.Results Fifty-four SD rats with an average weight of 250±25 g were operated successfully,and animal model of of free muscle transfer with nerve anastomosis was available.Muscle wet weight reservation rate(muscle weight of operative side /muscle weight of control side ×100 %) had a dramatically decrease in the first 4 weeks following the operation and increased gradually from then on,but remained lower compared with the control(p0.05).Transaction areas of muscular fiber at different stage postoperatively were calculated and exhibited a similar change with that of muscle wet weight.Then muscular function including maximum strength of single contraction and tetanus was successfully recorded using a multiple function physiological recording device.The recovery ratio was consistent with these index for muscular atrophy mentioned above.Conclusion Animal model of of free muscle transfer with nerve anastomosis using rat gracilis muscle was easy and stable.Muscle wet weight reservation rate and transection area of muscle fiber are better indexes for muscle atrophy following free transfer,according the results of muscle function." @default.
- W2380521643 created "2016-06-24" @default.
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- W2380521643 date "2007-01-01" @default.
- W2380521643 modified "2023-09-23" @default.
- W2380521643 title "Establishing an Experimental Animal Model of Free Muscle Transfer with Rat Gracilis Muscles" @default.
- W2380521643 hasPublicationYear "2007" @default.
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