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- W2380521928 abstract "Objective To observe the regulatory effect ofQutan Huayu Lishi Formulaon β-catenin,Cyclin D1,MMP-7 of the Wnt /β-catenin signaling pathway of human synoviocytes. Methods GSK-3β(Glycogen synthase kinase-3β) selective small molecule inhibitors in normal human synoviocytes(HS) were used to activate the Wnt /β-catenin signaling pathway. We extracted and detected nuclear β-catenin protein expression,thereby to determine the optimal activation time point. The synoviocytes in logarithmic phase were divided into the normal group,SB-216763 activation group,Qutan Huayu Lishi Formulagroup. The corresponding measures were used to each group. We detected the expressions of HS nuclear proteins β-catenin and its downstream gene Cyclin D1,MMP-7 were detected by Western Blotting. Expressions of Cyclin D1 and MMP-7 in culture supernatant fluid of synoviocytes were detected by ELISA. Results In this study,we have been successfully activated normal human synovial cells of Wnt /-catenin signaling pathway. After intervened by SB-216763,nuclear protein β-catenin and its downstream gene Cyclin D1 and MMP-7 expression of the activation group were significantly higher than those of the normal group( P 0. 05); after intervened by serum containingQutan Huayu Lishi Formula,the expressions of β-catenin,Cyclin D1 and MMP-7 of theQutan Huayu Lishi Formulagroup were significantly down-regulated,with significant difference from that of the activation group( P 0. 01). Conclusion This study confirms the GSK-3β as a selective small molecule inhibitor of human synovial cells capable of activating Wnt / β-catenin signaling pathway; after activating the pathway,its downstream genes Cyclin D1 and MMP-7 expressions were significantly increased; whileQutan Huayu Lishi Formulacan significantly lowered β-catenin,Cyclin D1,MMP-7expression results in favor of the signal path from a single aspect of interpretation dampness phlegm stasis treatment of osteoarthritis molecular mechanisms of inflammation." @default.
- W2380521928 created "2016-06-24" @default.
- W2380521928 creator A5084885231 @default.
- W2380521928 date "2014-01-01" @default.
- W2380521928 modified "2023-09-30" @default.
- W2380521928 title "Regulatory effect of “Qutan Huayu Lishi Formula” on β-catenin,Cyclin D1,MMP-7 of the Wnt /β-catenin signaling pathway of human synoviocytes" @default.
- W2380521928 hasPublicationYear "2014" @default.
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