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- W2380535316 abstract "Objective To investigate the effect of nodosin(active constituent from Herba Isodi Lophanthoidis)perfusion on rat liver grafts pathological injury ex vivo.Methods The rat models reserved perfusion with nodosin were established ex vitro.Rat livers were randomly divided into four groups and underwent the following treatments:perfusion with nodosin-H(200 μg/ml),nodosin-M(20 μg/ml),nodosin-L(10 μg/ml)and lactic Ringer's(control)respecitively.Histological injury was measured by Banff criteria and the microstructure was observed using an electron microscope.Rat orthotopic liver transplantation(OLT)was performed using the rat livers perfused with lactic Ringer's(control)or nodosin(200 μg/ml)ex vivo.The histological injury was measured with Suzuki criteria on day 1,day 3,day 7 and day 21 after OLT.Results There was no significant difference in Banff scores between nodosin treatment group and control group,respectively.The grafts perfused with nodosin showed no obvious morphological damage under electron microscopy examination.On day 1,day 3,day 7 after OLT,there was no significant difference in Suzuki scores between nodosin(200 μg/ml)group and control group.On day 21 after OLT,there was statistical difference between the two groups(P0.01).Conclusion No histological damage is observed in the liver grafts perfused with nodosin(200 μg/ml)ex vivo." @default.
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- W2380535316 date "2011-01-01" @default.
- W2380535316 modified "2023-09-24" @default.
- W2380535316 title "Effect of nodosin perfusion on rat liver grafts pathological injury" @default.
- W2380535316 hasPublicationYear "2011" @default.
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