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- W2380536114 abstract "Objective To investigate the effects of inhalation of different concentrations of isoflurane on global and regional cerebral glucose metabolic rate (CMRglu) in healthy volunteers using positron emission tomography (PET) scan.Methods The study was approved by the ethic committee of the hospital. After obtaining written informed consent we studied eight right-handed healthy volunteers (3 male, 5 female), aged 21-28 yrs. Each volunteer underwent 3 PET scans.They were fasted for 8 h prior to study. The PET scan was performed when conscious, at 0.5 and 1.0 MAC isoflurane anesthesia. The interval between two PET scans was 1 week. Scans were obtained with a MASEP CPET Plus scanner (2.0 mm resolution-FWHM) using the 18 fluorodeoxyglucose technique. Results The whole brain CMRglu averaged 30.0±1.1 μmol·100 mg-1·min-1 when the volunteer was awake. Isoflurane anesthesia significantly reduced whole-brain CMRglu by 24% to 23.3±1.4 μmol·100 mg-1·min-1 at 0.5 MAC and by 41% to 18.4±0.9 μmol·100mg-1·min-1 at 1.0 MAC (P0.05, 0.01). Regional CMRglu was also significantly reduced by isoflurane anesthesia in a MAC - dependent manner especially thalamus, and cuneus and cingulated gyrus. Conclusion Whole brain as well as regional CMRglu decreases significantly during isoflurane anesthesia especially thalamus and cuneus and cingulated gyrus." @default.
- W2380536114 created "2016-06-24" @default.
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- W2380536114 date "2004-01-01" @default.
- W2380536114 modified "2023-09-24" @default.
- W2380536114 title "Effect of isoflurane on cerebral glucose metabolic rate in humans" @default.
- W2380536114 hasPublicationYear "2004" @default.
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