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- W2380545786 abstract "Objective:To investigate the suppressive effects of Chailing-tang and its components on mesangioproliferative nephritis.Methods:The irreversible renal lesions were initiated by uninephrectomy and anti-thy-1 antibody 1-22-3(mAb 1-22-3) injection.Twenty-eight rats were divided into four groups of seven.Urine samples were collected from the rats in metabolic cages on days 1,3,7,14,21 after the injection.All rats were sacrificed on day 21 after the injection of mAb 1-22-3 for blood biochemistry,immunofluorescent and light microscopy of the kidney.Results:Chailing-tang and its components suppressed proteinuria,extracelluar matrix expansion,crescentic formation as well as the expression of transforming growth factor-β(TGF-β),α-Smooth muscle actin and collagen type I in the glomeruli.Conclusion:Chailing-tang and its active components prevent the progression of mesangioproliferative nephritis in rats,probably associated with significant suppressive effects of the drugs on glomerular TGF-β expression." @default.
- W2380545786 created "2016-06-24" @default.
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- W2380545786 date "2006-01-01" @default.
- W2380545786 modified "2023-09-24" @default.
- W2380545786 title "Suppressive Effect of Chailing-tang and its Components on Mesangioproliferative Nephritis in Rats" @default.
- W2380545786 hasPublicationYear "2006" @default.
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