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- W2380551009 abstract "Objective To investigate the cause of venous thrombosis associated with antiphospholipid syndrome (APS).Methods The plasma levels of protein C activity(PC:A),protein S activity(PS:A)and antithrombin activity(AT:A) were detected using chromogenic assay.Protein C antigen(PC:Ag),plasminogen antigen(PLG:Ag),tissue plasminogen activator antigen(t-PA:Ag),plasminogen activator inhibitor-1 antigen(PAI-1:Ag),α_2-antiplasmin antigen(α_2-AP:Ag)and anticardiolipin antibodies(ACA)were measured by an enzyme-linked immunosorbent assay(ELISA).Resistance to activated protein C(APC-R)was studied by an APTT-based(clotting)assay and expressed as the ratio between the APTT obtained in the presence and absence of exogenous APC,the ratio lower than 2.0 was regarded as APC-R positive.Lupus anticoagulant(LA)was detected by commercial kits,based on dRVVT.The PC gene,F(?)Leiden and prothrombin G20210A mutation were amplified by polymerase chain reaction(PCR)and directly sequenced.Results The presence of LA and APC-R was associated with the decreased PC:A level and the augmented PC:Ag level.All exons of PC gene were identified as normal.Neither FV Leiden mutation nor prothrombin G20210A mutation were found in the patient. Conclusions LA may cause thrombosis via interfering the activity of protein C.Combined detection of ACA,APC-R and antigen and activity of anticoagulation proteins may be useful for the etiological diagnosis of thrombotic diseases." @default.
- W2380551009 created "2016-06-24" @default.
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- W2380551009 date "2008-01-01" @default.
- W2380551009 modified "2023-09-23" @default.
- W2380551009 title "Antiphospholipid syndrome associated with venous thrombosis and abnormal protein C activity" @default.
- W2380551009 hasPublicationYear "2008" @default.
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