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- W2380555655 abstract "Objective:To investigate the inhibitory effects of As2O3 and Aspirin on cell proliferation in human gastric carcinoma cells(SGC-7901 cell lines).Methods:The inhibition of proliferation,apoptosis and cell cycle of gastric cancer cells SGC-7901 were detected by MTT assay and the flow cytometry and light microscope.Results:①After 72 hours,MTT assay showed the growth of the SGC-7901 cells was inhibited by As2O3(4 μmol/L),Aspirin(2 mmol/L),and As2O3+Aspirin(2 μmol/L + 1 mmol/L).And the inhibitory rates were 31.04%,16.11% and 24.19% respectively.It also showed the inhibitory effects among negative control group,two single drug groups(As2O3 group,Aspirin group) and drug combination group(P 0.05).②Flow cytometry showed the apoptosis rates were 1.55% in negative group,1.81% in As2O3 group,1.64% in Aspirin group and 19.01% in As2O3+Aspirin group,which showed statistical significance(P 0.05).③The proportion of cells at G0/ G1 phase was significantly decreased while the proportion of cells at G2/ M phase was increased in As2O3 group.The proportion of cells at G0/ G1 phase was significantly increased while the proportion of cells at S phase and G2/ M phase were decreased in Aspirin group.And the increasing of proportion of cells at G0/ G1 phase and G2/ M phase were found in drug combination group,while proportion of cells at S phase decreased.Conclusion:As2O3 and Aspirin could inhibit the growth of gastric cancer cell SGC-7901 by inducing apoptosis and cell cycle arrest.It showed that inhibitory effect on proliferation of SGC-7901 cell line in drug combination group(As2O3+Aspirin) were markedly enhanced and their dose was decreased." @default.
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- W2380555655 date "2008-01-01" @default.
- W2380555655 modified "2023-09-28" @default.
- W2380555655 title "Inhibitory effects of As_2O_3 and Aspirin on cell proliferation in human gastric carcinoma cell line SGC-7901" @default.
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