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- W2380556645 abstract "Objective Research has demonstrated that phenylacetate(PA) can inhibit growth and induce differentiation in rat C6 glioma cell line. But the mechanisms of PA action are still incompletely understood. This study is aimed to identify which Hox gene is related to glioma and to observer the change of expression on mRNA level treated by phenylasetate. Methods 22 kinds of Hox gene divided into 3 groups according to their primer sequence. Semiquantitative reverse transcription-polymerase chain reaction(RT-PCR) used to investigate the mRNA expression of Hox gene groups and some kind of Hox gene in rat C6 glioma cell line following differentiation induced by PA. The level of Hox gene expression was expressed as ratio expression rate(RER) of Hox gene/β-actin according to Computer Image analysis and the difference between C6 cells and PA treated C6 cells was analyzed by student t-test. Results It was found that Hox genes matching to primers P2 were weakly expressed in C6 cells(0.682 5±0.098 70.881 7±0.073 1, 0.860 8±0.088 1, P0.001), the expression of HoxB2 mRNA was significantly up-regulated in PA treated C6 cells(0.776 3±0.124 10.483 9±0.134 3, P0.001). Conclusion It can be inferred from these findings that the weak expression of HoxB2 maybe involved in glioma origin and the mechanisms of PA action are correlated with transcription process in glioma cells." @default.
- W2380556645 created "2016-06-24" @default.
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- W2380556645 date "2004-01-01" @default.
- W2380556645 modified "2023-09-24" @default.
- W2380556645 title "The expression of HoxB2 gene mRNA on glioma cell line C6" @default.
- W2380556645 hasPublicationYear "2004" @default.
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