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- W2380557085 abstract "Objectives To investigate the expression of TGF-βreceptors and signaling protein SMADs mRNA in psoriatic lesional and nonlesional skin,and to analyze their role in the pathogenesis of psoriasis.Methods Expression of TGF-βreceptorⅠ,TGF-βreceptorⅡmRNA and different SMADs(SMAD2,3,4,6,7)mRNA was investigated by real time PCR method in lesional and nonlesional skin of13psoriatic patients and10normal controls.Results The mRNA expression of TGF-βreceptors and all kinds of SMADs was significantly down-regulated in psoriatic lesional skin compared with normal skin con-trols(P0.05or P0.01).However,no significant differences of TGF-βreceptors and SMAD2,3,6,7mRNA expression were found between nonlesional skin and normal skin controls(P0.05).Conclusions There is down-regulated TGF-βpathway in psoriatic lesional skin,which may further indicate that lack of TGF-βmediated growth inhibition might play an important role in the pathogenesis of psoriasis." @default.
- W2380557085 created "2016-06-24" @default.
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- W2380557085 date "2004-01-01" @default.
- W2380557085 modified "2023-09-22" @default.
- W2380557085 title "Down-regulation of Expression of TGF-βReceptors and SMADs mRNA in Psoriatic Lesional Skin" @default.
- W2380557085 hasPublicationYear "2004" @default.
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