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- W2380557977 abstract "Purpose To investigate the clinicopatholgical features of giant cell angiofibroma(GCA).Methods The clinicopathological features were analyzed in 3 cases of GCA,and the literatures were reviewed.Results The age of the 3 patients were 15,45 and 69 years old,there was 1 male(eyelid) and 2 females(scapular region、orbital).All of the cases presented with slowly growing,painless masses.Grossly,they were well-circumscribed tumors.Microscopically,the tumors revealed three patterns and two cells: hypercellular and hypocellular area in tumor;The tumor was characterized by a prominent network of blood vessels and irregular cleftlike or sinusoid psendovascular spaces that were lined with a layer of discontinuous multinucleate giant cells,and was composed of a patternless proliferation of round,ovoid or short spindle cells.Both nuclear atypia and mitotic activity were absent.The stroma displayed a variable degree of collagenization or myxoid degeneration with some areas recapitulating the patternless pattern of solitary fibrous tumor.Immunohistochemically,tumour cells were positive for CD34,CD99,vimentin and Bcl-2.Conclusions Giant cell angiofibroma is a distinctive benign lesion or potentially a tumor of low-grade malignancy,which occurred predominantly in the orbit or extraorbital in adults.Histologically,this rare entity should be distinguished from giant cell fibroblastoma,extrapleural solitary fibrous tumor and so on." @default.
- W2380557977 created "2016-06-24" @default.
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- W2380557977 date "2011-01-01" @default.
- W2380557977 modified "2023-10-01" @default.
- W2380557977 title "Clinicopatholgical features of giant cell angiofibroma" @default.
- W2380557977 hasPublicationYear "2011" @default.
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