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- W2380558105 abstract "Objective:To establish a liquid chromatography-mass spectrometry(LC-MS) method for determination of diclofenac in human plasma.Methods:The drug and an internal standard(glipizide) were extracted from plasma with ethyl acetate.The compounds were separated on a Agilent ZORBAX SB-C18(150 mm×4.6 mm,5 μm) column by Agilent LC-MS with 0.01 mol·L-1 ammonium acetate-methanol(35∶65) as the mobile phase at a flow rate of 0.5 mL·min-1.The detection was carried out by means of electrospray ionization mass spectrometry in positive ion mode.Selective ion(SIM) mode was used.Results:The assay had the calibration range from 3.936 0 to 492.000 0 ng·mL-1 and the lower limit of quantification(LOQ) was 3.936 0 ng·mL-1 for diclofenac.The accuracy,precision(intra-day and inter-day),sensitivity,specificity and stability(ambient temperature,freeze/thaw,freeze storage) of the method fulfilled the analytical validation criteria of the guideline.Conclusion:The method is simple,accurate,sensitive and specific for determination of diclofenac in human plasma." @default.
- W2380558105 created "2016-06-24" @default.
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- W2380558105 date "2011-01-01" @default.
- W2380558105 modified "2023-09-24" @default.
- W2380558105 title "Determination of diclofenac in human plasma by LC-MS" @default.
- W2380558105 hasPublicationYear "2011" @default.
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