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- W2380580018 abstract "Objective To study the expression level of aquaporin-4(AQP-4) in brain of rats and mice infected by Angiostrongylus cantonensis(A.cantonensis),and clarify the relationship of AQP-4 and brain edema.Methods The mRNA level of AQP-4 in brain tissue of infected rats,infected mice and minocycline treated infected mice were detected by Real-time PCR after A.cantonensis infection 0 d,7 d,14 d and 21 d.The water content of mice brain was also measured.Results AQP-4 mRNA level in rats brain increased after 7 days infection and did not rise at other time points.However,AQP-4 level increased continuously after infection in mice brain.When mice were treated by minocycline,the mRNA level of AQP-4 decreased evidently.At the same time,the water content of minocycline treated mice brain tissue was reduced comparing with the untreated infected mice.Conclusion The high level of AQP-4 in mice brain was associated with brain edema which was induced by A.cantonensis,and microglia may regulate this progress." @default.
- W2380580018 created "2016-06-24" @default.
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- W2380580018 date "2013-01-01" @default.
- W2380580018 modified "2023-09-25" @default.
- W2380580018 title "Study on the expression level of AQP-4 in rats and mice brain infected by Angiostrongylus cantonensis" @default.
- W2380580018 hasPublicationYear "2013" @default.
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