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- W2380588369 abstract "To evaluate the effect of FK506 on kinetic activity of IFN-γ and IL-2 in serum,and parasite load in liver in mice infected with Toxoplasma gondii(T.gondii).One hundred and twenty mice were infected with T.gondii by intraperitoneal injection of 10~2 tachyzoites.Then the mice were assigned randomly into 2 groups.FK506(1mg/(kg.d)) was given to mice in group A orally and normal solution was given to mice in group B.At 2, 4,6,7 and 9 days after infection,8 mice were killed each time to collect the blood sera and livers respectively.The activities of IFN-γ and IL-2 in serum were assayed by biological method and parasites loads in livers were determined with quantitative fluorescence polymerase chain reaction(PCR).The normal value of IFN-γ and IL-2 was acquired from another 8 healthy mice.It was found that the mice died on day 8 after infection in group A and on day 10 in group B.The activity of IFN-γ in group A on day 2,4,6,7 after infection was significantly lower than that in group B(P 0.05 or P 0.01),the activity of IL-2 on day 4,6,7 after infection in group A was significantly lower than that in group B(P 0.05 or P 0.01) except that on day 2 after infection,the parasites loads in livers at 4d and 7d after infection in group A were significantly higher than that in group B(P 0.01).In conclusion,the protective immunity after acute T.gondii infection can be inhibited by FK506 and as a result,mass parasites reproduced and led to earlier death of hosts." @default.
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- W2380588369 date "2006-01-01" @default.
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- W2380588369 title "The effect of FK506 on kinetic activity of IFN-γ,IL-2 and parasite load in liver in mice with Toxoplasmosis" @default.
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