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- W2380624790 abstract "Objective To investigate the effects of proADM N-terminal 20 peptide (PAMP) on the proliferation and collagen synthesis of rat cardiac fibroblasts (CFs) induced by Angiotensin Ⅱ(AngⅡ). Methods CFs of neonatal Sprague-Dawley (SD) rats were isolated with trypsin digestion method and those growth arrested were stimulated with various concentrations of PAMP, various concentrations of AngⅡand 10-7mol/ L AngⅡin the presence of various concentrations of PAMP. The collagen synthesis of CFs was measured with 3H (3H) incorporation. MTT colorimetry was adopted to evaluate cell number. Group:①blank group;②10-9、10-8、10-7、10-6 mol/L AngⅡgroups;③10-9、10-8、10-7、10-6 mol/L PAMP groups;④10-7 mol/L AngⅡ+PAMP(10-9、10-8、10-7、10-6 mol/L) groups. Results ①A490 values of PAMP groups were not significantly changed(F=10.21, P 0.05); AngⅡincrease A490 values in CFs in a concentration dependent manner(P 0.01). A490 values of AngⅡ+PAMP groups were significantly lower in comparison with 10-7mol/ L AngⅡgroup (P 0.01).②3H incorporation values of PAMP groups were not significantly changed(F=16.92, P 0.05); AngⅡincrease 3H incorporation in CFs in a concentration dependent manner(P 0.01). 3H incorporation in CFs value of AngⅡ+PAMP groups was significantly lower in comparison with 10-7 mol/ L AngⅡgroup (P 0.01). Conclusions It is suggested that PAMP can decrease CFs number and collagen synthesis induce by AngⅡand may play an important role in the CFs proliferation." @default.
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- W2380624790 date "2005-01-01" @default.
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- W2380624790 title "The inhibitory effects of PAMP on the proliferation and collagen synthesis in rat cardiac fibroblasts induced by AngII" @default.
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