Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380635845> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2380635845 abstract "Objective To study the effect of berberine on the lipid metabolism and the expression of ox-LDL,CD36 and PPARγ in the peritoneal macrophage(PM) and alveolar macrophage(AM) from the type 2 diabetic rats. Methods Sprague-Dauley rats were randomly divided into groups of normal control,high-fat diet,type 2 diabetes and berberine treatment.The levels of blood glucose,insulin and lipid were measured biochemically,the content of ox-LDL in macrophage and the protein expression of CD36 and PPARγ in macrophage were assayed by ELISA,the mRNA expression of CD36 and PPARγ in macrophage was disclosed by RT-PCR. Results Compared with the control group, the levels of glucose,insulin and total cholesterol (TC),triglycerides(TG),low density lipoprotein-cholesterol (LDL-C) in blood were increased significantly(P0.01),and high density lipoprotein-cholesterol (HDL-C)was decreased(P0.01) in type 2 diabetic group.The berberine treatment decreased blood glucose,insulin, LDL-C(P0.05) and TC, TG(P0.01),but increased the HDL-C level(P0.05). The content of ox-LDL,the protein and mRNA expressions of CD36 and PPARγ in PM and AM increased in type 2 diabetic group(P0.01),while the levels of ox-LDL,the expressions of protein and mRNA of CD36 and PPARγ in PM and AM decreased in berberine treatment group(P0.01 or P0.05). Conclusions Berberine may prevent the development of diabetic complication by correcting insulin resistance and ameliorating the disturbance of lipid metabolism.The decreasing of ox-LDL and the inhibiting of the expression of CD36 and PPARγ in macrophages may contribute to the prevention." @default.
- W2380635845 created "2016-06-24" @default.
- W2380635845 creator A5075003346 @default.
- W2380635845 date "2008-01-01" @default.
- W2380635845 modified "2023-09-24" @default.
- W2380635845 title "Effect of berberine treatment on the expressions of oxLDL,CD36 and PPARγ of macrophages from diabetic rats" @default.
- W2380635845 hasPublicationYear "2008" @default.
- W2380635845 type Work @default.
- W2380635845 sameAs 2380635845 @default.
- W2380635845 citedByCount "0" @default.
- W2380635845 crossrefType "journal-article" @default.
- W2380635845 hasAuthorship W2380635845A5075003346 @default.
- W2380635845 hasConcept C126322002 @default.
- W2380635845 hasConcept C134018914 @default.
- W2380635845 hasConcept C139572402 @default.
- W2380635845 hasConcept C170493617 @default.
- W2380635845 hasConcept C185592680 @default.
- W2380635845 hasConcept C187345961 @default.
- W2380635845 hasConcept C2777180221 @default.
- W2380635845 hasConcept C2777391703 @default.
- W2380635845 hasConcept C2778163477 @default.
- W2380635845 hasConcept C2779306644 @default.
- W2380635845 hasConcept C2779828298 @default.
- W2380635845 hasConcept C2780072125 @default.
- W2380635845 hasConcept C2780116568 @default.
- W2380635845 hasConcept C41443022 @default.
- W2380635845 hasConcept C4733338 @default.
- W2380635845 hasConcept C55493867 @default.
- W2380635845 hasConcept C555293320 @default.
- W2380635845 hasConcept C71924100 @default.
- W2380635845 hasConceptScore W2380635845C126322002 @default.
- W2380635845 hasConceptScore W2380635845C134018914 @default.
- W2380635845 hasConceptScore W2380635845C139572402 @default.
- W2380635845 hasConceptScore W2380635845C170493617 @default.
- W2380635845 hasConceptScore W2380635845C185592680 @default.
- W2380635845 hasConceptScore W2380635845C187345961 @default.
- W2380635845 hasConceptScore W2380635845C2777180221 @default.
- W2380635845 hasConceptScore W2380635845C2777391703 @default.
- W2380635845 hasConceptScore W2380635845C2778163477 @default.
- W2380635845 hasConceptScore W2380635845C2779306644 @default.
- W2380635845 hasConceptScore W2380635845C2779828298 @default.
- W2380635845 hasConceptScore W2380635845C2780072125 @default.
- W2380635845 hasConceptScore W2380635845C2780116568 @default.
- W2380635845 hasConceptScore W2380635845C41443022 @default.
- W2380635845 hasConceptScore W2380635845C4733338 @default.
- W2380635845 hasConceptScore W2380635845C55493867 @default.
- W2380635845 hasConceptScore W2380635845C555293320 @default.
- W2380635845 hasConceptScore W2380635845C71924100 @default.
- W2380635845 hasLocation W23806358451 @default.
- W2380635845 hasOpenAccess W2380635845 @default.
- W2380635845 hasPrimaryLocation W23806358451 @default.
- W2380635845 hasRelatedWork W1901045332 @default.
- W2380635845 hasRelatedWork W1970439753 @default.
- W2380635845 hasRelatedWork W1981227680 @default.
- W2380635845 hasRelatedWork W1990837317 @default.
- W2380635845 hasRelatedWork W2051886073 @default.
- W2380635845 hasRelatedWork W2069297513 @default.
- W2380635845 hasRelatedWork W2096556016 @default.
- W2380635845 hasRelatedWork W2302228386 @default.
- W2380635845 hasRelatedWork W2348035649 @default.
- W2380635845 hasRelatedWork W2348293152 @default.
- W2380635845 hasRelatedWork W2354954060 @default.
- W2380635845 hasRelatedWork W2381814545 @default.
- W2380635845 hasRelatedWork W2502201430 @default.
- W2380635845 hasRelatedWork W2568617469 @default.
- W2380635845 hasRelatedWork W2994154698 @default.
- W2380635845 hasRelatedWork W3000827307 @default.
- W2380635845 hasRelatedWork W3148948011 @default.
- W2380635845 hasRelatedWork W3149884287 @default.
- W2380635845 hasRelatedWork W3176744252 @default.
- W2380635845 hasRelatedWork W857736849 @default.
- W2380635845 isParatext "false" @default.
- W2380635845 isRetracted "false" @default.
- W2380635845 magId "2380635845" @default.
- W2380635845 workType "article" @default.