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- W2380637040 abstract "Objective To determine the half effective dose(ED50)of remifentanil dose for tracheal intubation without neuromuscular relaxant in adult when combined with different concentration of sevoflurane.Methods Sixty ASA Ⅰ to Ⅱ adult aged 20 to 59 years old,scheduled for elective surgery under general anesthesia were enrolled in this study between July 2009 to November 2009.All patients were ranged randomly into Group Ⅰ(2% sevoflurane) and Group Ⅱ(3% sevoflurane).Anesthesia was induced with 8% sevoflurane in 100% oxygenat at 6 L/min.After the loss of eyelash reflex,remifentanil was injected over 30 s,end-tidal sevoflurane concentration 2% or 3% was maitained.The dose of remifentanil was determined by up-and-down method.In 90 s after the end of bolus administration of remifentanil,the trachea was intubated.Mean blood pressure and heart rate were recorded at anaesthetic induction,the loss of eyelash reflex,before,in 1 min and 3 min after intubation.Results ED50 values (95% confidence intervals) of remifentanil for tracheal intubation during 2% and 3% sevoflurane induction without neuromuscular relaxant were 0.585 μg/kg and 0.533-0.626 μg/kg,and 0.492 μg/kg and 0.451-0.572 μg/kg,respectively.Conclusion ED50 values(95% confidence intervals)of remifentanil for tracheal intubation 2% and 3% sevoflurane induction without neuromuscular relaxant are 0.585 μg/kg (0.533-0.626 μg/kg) and 0.492 μg/ kg (0.451-0.572 μg/kg),respectively." @default.
- W2380637040 created "2016-06-24" @default.
- W2380637040 creator A5067652454 @default.
- W2380637040 date "2010-01-01" @default.
- W2380637040 modified "2023-09-25" @default.
- W2380637040 title "The Half Effective Dose of Remifentanil for Tracheal Intubation with Different Concentration of Sevoflurane without Neuromuscular Relaxant in Adult" @default.
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