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- W2380647682 abstract "Objective To investigate effective way of Yiguanjian to improve the process of liver fibrosis in mice. Methods205 mice were divided into 185 rats named model group and 20 rats named normal control group,liver fibrosis model was prepared with dimethylnitrosamine,the model group were randomly divided into 3 groups after modeling: Yiguanjian group,positive control group(hepatocyte growth factor group,HGF group) and blank control group. The group treated with Yiguanjian Decoction were treated with intragastric administration. HGF group was treated with hepatocyte growth factor by subcutaneous injection,the control group were treated with normal saline by subcutaneous injection,the total treatment was four weeks. The general condition of mice,serum biochemistry,HE staining,tissue immunohistochemistry were appllied to detect effect of YGJ,differentiation and related factors affected in modeling for 2 weeks,4 weeks and treatment for 2weeks,4 weeks. Results(1) With Yiguanjian treatment,the a small amount of ascites symptoms and so on were improved,the mortality rate decreased gradually.(2) Model group 4 weeks of liver function in the ALT,AST,TBIL,DBIL,ALP were markedly elevated compared with normal control group(P 0. 05),A1 B,CHE was lower than the control group(P 0. 05). After Yiguanjian treatment,ALT and AST decreased significantly in the fourth week than that in the second week; ALB increased significantly during the second week(P = 0. 001); CHE in the fourth week did increase significantly higher(P = 0. 000) than that in the model,and the fourth week there was a significant increase compared with the second week(P = 0. 001); ALP did decrease significantly in the fourth week(P = 0. 037); TBIL,DBIL,GGT before and after the treatment had no significant meaning.(3) It could be detected in YGJ group like slightly enlarged part of the liver,brown and smooth surface,which were more complete microscopic structure of the liver tissue and less liver cell degeneration and necrosis compared with the model group. α-SMA expression of Yiguanjian group 4 weeks was weak positive,compared with blank treatment group with strongly positive expression.(4) The positive staining of SDF-1 / CXCR4 and ERK1 + 2 in Yiguanjian group 4 week were more than that in Yiguanjian group 2 weeks. The positive staining of Wnt-1 / β-catenin and NF-κB p65 in Yiguanjian group 2 week was less than that in Yiguanjian group 4 week. Conclusion YGJ could improve the efficacy of liver fibrosis. A variety of signal factor such as SDF-1 / CXCR4,Wnt-1 / β-catenin,NF-κB p65,ERK1 + 2 were refered in liver fibrosis reversal process. Yiguanjian play a role through the above mechanisms." @default.
- W2380647682 created "2016-06-24" @default.
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- W2380647682 date "2014-01-01" @default.
- W2380647682 modified "2023-09-23" @default.
- W2380647682 title "Efficacy studies of Yiguanjian treatment in mice fibrosis induced by dimethylnitrosamine" @default.
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