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- W2380648022 abstract "Objective:The effective principle with protective effect on radiation injury from Scutellaria baicalensis Georgi (SBG) was found and studied. Methods:The heated extracted aqueous liquid from SBG was acidified and kept hot for 50 minutes in 80℃,the flavonoids of SBG (FSBG) were precipitated and removed by filter.A precipitate (Ⅰ) from the filtered solution was obtained by the classical separation process.Tests were conducted on mice to detect whether (Ⅰ) is effective for protection against γ ray irradiation.Intraperitoneal injection(ip) of (Ⅰ) 1 g/kg and 2 g/kg in NIH female mice 35～45 minutes befores 7.7～8.7 Gy of whole body 60Co irradiation were conducted,the survival effects,30 days survival rate and in case of ip of (Ⅰ) 2 g /kg the WBC,PLT,RBC and HGB were observed on 4th and 12th day after 4.0 Gy exposure. Results:Positive reactions were shown with following chemical reagents:ferric chloride,Molisch,Fehling reagents on FSBG and (Ⅰ),however,concentrated sulfuric acid,alkaline reagents and hydrochloric acid Mg powder showed positive reaction on FSBG,but negative on (Ⅰ).Intraperitoneal injection of (Ⅰ) 1 g/kg and 2 g/kg increased the survival effects(1.35～2.08,the ratio of mean survival time in a treated group to that of the control group in 30 d after irradiation) and 30 days survival rate (8.33～41.46%in treated and 0～2.50%in control group,respectively) significantly in comparison with control mice.In cases of ip of (Ⅰ) 2 g/kg the WBC,PLT,RBC and HGb were all increased on 4 th and 12 th day after 4.0 Gy exposure as compared with control.Conclusions:1 The different coloration to chemical reagents (concentrated sulfuric acid and etc.) showed that there are different chemical structures between(Ⅰ) and FSBG.The positive reactions (ferric chloride and etc.) suggested that the main constituent of (Ⅰ) was a chemical type of glycoside with phenolic hydroxyl group. 2 The glycoside with phenolic hydroxyl group exhibited good radioprotective effect against whole body lethal irradiation of mice.3 The study may be considered as new application of SBG." @default.
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- W2380648022 date "1999-01-01" @default.
- W2380648022 modified "2023-09-25" @default.
- W2380648022 title "Study on the protective effect on radiation injury of mice by glycoside with phenolic hydroxyl group from Scutellaria baicalensis Georgi" @default.
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