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- W2380653225 abstract "Objectives: To investigate the effects of androgen on the function and structure of rat penile corpus cavernosum and to study whether the nitric oxide synthase(NOS) activity and apoptosis are associated with androgen in penile erection. Methods: Thirty mature rats were randomized into 3 groups: castrated group, tesostesterone-sabstituted group given testosterone injection after castration and sham-operated control. One week after castration,the corpus cavernosum was harvested. NOS activity was detected by ultraviolet spectrophotometry and apoptosis was examined by ISEL(in situ end labeling) technique. Results: Castration decreased NOS activity by 70% and induced apoptosis in the erectile tissue(P0.01,P0.05).Conclusion: Androgen may maintain the structure and function of penile corpus cavernosum by regulating NOS activity, cell proliferation and apoptosis." @default.
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- W2380653225 date "2003-01-01" @default.
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- W2380653225 title "Effects of castration on apoptosis of rat penis" @default.
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