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- W2380663292 abstract "To explore the relationship between apoptosis of liver cells and Caspase-3 in endotoxemia and protection of cation A(CA) in rats.72 adult healthy SD rats were randomly divided into control group(groupⅠ),ET group(groupⅡ) and CA group(groupⅢ).Hepatic tissues of three groups were collected for tests at 3rd,4th,8th and 12th hour after treatment.Apoptosis of liver cells was detected by flow cytometry,and expression of Survivin were detected by immunohistochemical staining.The results showed that the percentage of apoptosis of liver cells in group Ⅱwas significantly higher than that of groupⅠ and group Ⅲ.The percentage of hepatocyte apoptosis of Ⅱ group was in an upward trend,group Ⅲ trended upward at 3rd,4th,8th,and trended downward at the 12th hour.Survivin expression in group Ⅱ was significantly lower than group Ⅰ(P0.01),with decreasing trend,in group Ⅱwas significantly less than group Ⅲ(P0.01),group Ⅲ decreased at 3rd,4th,8th and increased at 12th hour.These above results suggested that apoptosis and Survivin protein expression in liver cell was a negative correlation in endotoxemia,and CA have a significant protection against inflammatory injure through up-regulation of the expression of Caspase-3 pathway in liver,and inhibiting liver cell apoptosis." @default.
- W2380663292 created "2016-06-24" @default.
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- W2380663292 date "2012-01-01" @default.
- W2380663292 modified "2023-09-24" @default.
- W2380663292 title "Relationship between apoptosis of liver cells and expression of Survivin in endotoxemia and protection of cation A" @default.
- W2380663292 hasPublicationYear "2012" @default.
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