Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380663837> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2380663837 endingPage "315" @default.
- W2380663837 startingPage "310" @default.
- W2380663837 abstract "Aim To explore IL-6 neuroprotection against glutamate-induced neurotoxicity and primary mechanisms involved in this neuroprotection. Methods The cerebellar granule neurons from postnatal 8-day infant rats were chronically exposed to IL-6 for 8 days, and then glutamate stimulated the cultured cerebellar granule neurons for 15 min. Methyl-thiazole-tetrazolium (MTT) assay and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method were used to observe the changes of neuronal vitality and apoptosis, respectively. Laser scanning confocal microscope (LSCM) and reverse transcription-polymerase chain reaction (RT-PCR) were respectively employed to measure dynamic changes of intracellular Ca2+ levels and expression of gp130 mRNA, a 130-kDa intracellular IL-6 signal-transduction protein, in the neurons. Results The chronic IL-6 (2.5, 5 and 10 ng/ml) pretreatment of the cultured cerebellar granule neurons remarkably improved the decreased neuronal vitality by glutamate in a concentration-dependent manner. The neuronal apoptosis induced by glutamate was significantly attenuated by the chronic IL-6 pretreatment. The intracellular Ca2+ overload evoked by glutamate was also inhibited by the chronic IL-6 pretreatment. The expression of gp130 mRNA was dramatically lower in the IL-6-pretreated cerebellar granule neurons than in the IL-6-untreated neurons. Conclusion IL-6 can protect neurons against glutamate-induced exciting neurotoxicity. The mechanism of IL-6 neuroprotection may be closely related to the suppression of glutamate-induced intracellular Ca2+ overload and mediated by gp130 intracellular signal transduction pathways." @default.
- W2380663837 created "2016-06-24" @default.
- W2380663837 creator A5004367491 @default.
- W2380663837 creator A5029563117 @default.
- W2380663837 creator A5089859116 @default.
- W2380663837 date "2006-08-01" @default.
- W2380663837 modified "2023-09-24" @default.
- W2380663837 title "[Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity]." @default.
- W2380663837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21158076" @default.
- W2380663837 hasPublicationYear "2006" @default.
- W2380663837 type Work @default.
- W2380663837 sameAs 2380663837 @default.
- W2380663837 citedByCount "0" @default.
- W2380663837 crossrefType "journal-article" @default.
- W2380663837 hasAuthorship W2380663837A5004367491 @default.
- W2380663837 hasAuthorship W2380663837A5029563117 @default.
- W2380663837 hasAuthorship W2380663837A5089859116 @default.
- W2380663837 hasConcept C153911025 @default.
- W2380663837 hasConcept C169760540 @default.
- W2380663837 hasConcept C170493617 @default.
- W2380663837 hasConcept C178790620 @default.
- W2380663837 hasConcept C185592680 @default.
- W2380663837 hasConcept C190283241 @default.
- W2380663837 hasConcept C196795494 @default.
- W2380663837 hasConcept C25498285 @default.
- W2380663837 hasConcept C2779491297 @default.
- W2380663837 hasConcept C2779652256 @default.
- W2380663837 hasConcept C29730261 @default.
- W2380663837 hasConcept C55493867 @default.
- W2380663837 hasConcept C61174792 @default.
- W2380663837 hasConcept C79879829 @default.
- W2380663837 hasConcept C86803240 @default.
- W2380663837 hasConcept C95444343 @default.
- W2380663837 hasConcept C98274493 @default.
- W2380663837 hasConceptScore W2380663837C153911025 @default.
- W2380663837 hasConceptScore W2380663837C169760540 @default.
- W2380663837 hasConceptScore W2380663837C170493617 @default.
- W2380663837 hasConceptScore W2380663837C178790620 @default.
- W2380663837 hasConceptScore W2380663837C185592680 @default.
- W2380663837 hasConceptScore W2380663837C190283241 @default.
- W2380663837 hasConceptScore W2380663837C196795494 @default.
- W2380663837 hasConceptScore W2380663837C25498285 @default.
- W2380663837 hasConceptScore W2380663837C2779491297 @default.
- W2380663837 hasConceptScore W2380663837C2779652256 @default.
- W2380663837 hasConceptScore W2380663837C29730261 @default.
- W2380663837 hasConceptScore W2380663837C55493867 @default.
- W2380663837 hasConceptScore W2380663837C61174792 @default.
- W2380663837 hasConceptScore W2380663837C79879829 @default.
- W2380663837 hasConceptScore W2380663837C86803240 @default.
- W2380663837 hasConceptScore W2380663837C95444343 @default.
- W2380663837 hasConceptScore W2380663837C98274493 @default.
- W2380663837 hasIssue "3" @default.
- W2380663837 hasLocation W23806638371 @default.
- W2380663837 hasLocation W23806638372 @default.
- W2380663837 hasOpenAccess W2380663837 @default.
- W2380663837 hasPrimaryLocation W23806638371 @default.
- W2380663837 hasRelatedWork W1970204221 @default.
- W2380663837 hasRelatedWork W1976869427 @default.
- W2380663837 hasRelatedWork W1977505230 @default.
- W2380663837 hasRelatedWork W1982708706 @default.
- W2380663837 hasRelatedWork W1984199947 @default.
- W2380663837 hasRelatedWork W1988177646 @default.
- W2380663837 hasRelatedWork W1991538811 @default.
- W2380663837 hasRelatedWork W1993481957 @default.
- W2380663837 hasRelatedWork W1998071788 @default.
- W2380663837 hasRelatedWork W2014280596 @default.
- W2380663837 hasRelatedWork W2063207044 @default.
- W2380663837 hasRelatedWork W2064937763 @default.
- W2380663837 hasRelatedWork W2066054859 @default.
- W2380663837 hasRelatedWork W2073334350 @default.
- W2380663837 hasRelatedWork W2128471985 @default.
- W2380663837 hasRelatedWork W2352437322 @default.
- W2380663837 hasRelatedWork W2362747975 @default.
- W2380663837 hasRelatedWork W2368693067 @default.
- W2380663837 hasRelatedWork W2409643207 @default.
- W2380663837 hasRelatedWork W2906286762 @default.
- W2380663837 hasVolume "22" @default.
- W2380663837 isParatext "false" @default.
- W2380663837 isRetracted "false" @default.
- W2380663837 magId "2380663837" @default.
- W2380663837 workType "article" @default.