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- W2380683135 abstract "OBJECTIVE To investigate the effects of 2-ethyl-3-hydroxy-6-phenylthio-4-(1H)-pyridinone(HPP) on carbon tetrachloride (CCl 4) intoxicated primary cultured rat hepatocytes.METHODS The rat hepatocytes were separated by perfusion with collagenase solution.HPP was added into the culture medium after incubating the rat hepatocytes for 24 h.At the same time,10 mmol·L -1 CCl 4 was added to induce injury.The levels of ALT,malondialdehyde (MDA),glutathione Peroxidase (GSH-Px) and cell viability after cultivation for 24 h and 48 h were determined respectively.RESULTS HPP 0.3~40.0 mmol·L -1 significantly improved the number of cell viability,prevented the decrease of GSH-Px and decreased the GPT and MDA levels.CONCLUSION HPP 0.3~40.0 mmol·L -1 protected effectively the primary cultured rat hepatocytes against CCl 4 induced injury." @default.
- W2380683135 created "2016-06-24" @default.
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- W2380683135 date "2002-01-01" @default.
- W2380683135 modified "2023-09-23" @default.
- W2380683135 title "Protective effects of 2-ethyl-3-hydroxy-6-phenylthio-4-(1H)-pyridinone on injured primary cultured rat hepatocytes induced by CCl_4" @default.
- W2380683135 hasPublicationYear "2002" @default.
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