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- W2380685638 abstract "Objective To study the clinical and histopathologic characters of recurrent and de novo IgA nephropathy (IgAN) following cadaveric kidney transplantation, and investigate the prognosis. Method Three patients were diagnosed as having transplant IgAN from 36 patients with abnormal renal function (proteinuria, hematuria or/and elevated creatinine) by renal graft biopsy and histopathologic analysis . The patients were treated with dipyridamole, low dose warfarin and tripterygium wifordii and the therapeutic effects were observed. Results Three patients were respectively diagnosed as having de novo/recurrent membrano preliferative IgAN (lesion of grade Ⅲ) with moderate chronic allograft nephropathy at 30th month postoperatively, recurrent mesangial proliferative IgAN (grade Ⅱ) with mild chronic allograft nephropathy at 18th month postoperatively and de novo/recurrent mesangial proliferative IgAN (gradeⅡ) with mild chronic allograft nephropathy at 14th month postoperatively. All of then were treated with dipyridamole, low dose warfarin and tripterygium wifordii for 24 months, and unchanged basic immunosuppressive regimens (including CsA, MMF or Aza and Pred). The 3 patients kept a stable serum creatinie, improved macroscopic hematuria, and some amount of proteinuria during the treatment, but the first one with membrano preliferative IgAN had elevated serum creatinine (from 120 150?μmol/L up to 180 200?μmol/L) at 30th month maintenance of the treatment (60 months postoperation). Conclusions Recurrent or de novo IgAN in renal allograft occurred quickly, efficacious treatment had been not searched out yet, and prognosis had a close relationship with degree of histopathologic lesion, classification of IgAN." @default.
- W2380685638 created "2016-06-24" @default.
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- W2380685638 date "2001-01-01" @default.
- W2380685638 modified "2023-09-25" @default.
- W2380685638 title "Three cases of IgA nephropathy following cadaveric renal transplantation and review" @default.
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