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- W2380694534 abstract "The objective of research is to investigate radioimmunoirnaging (RII) on ovarian tumor by labelling anti-ovarian cancer monoclonal antibody (OC125) with 99mTc. The nude mice models were produced by injection ovarian serous cystadenocarcinoma cell HO8910. Experimental group was injected with 99mTc-OC125 as tracer and control groups were injected normal mice IgG labelled with 99mTc and anti-HO8910 antibody labelled with 99mTc. RII using 99mTc-OC125 McAb was also performed on 4 nude mice model of glioma (control group). Imaging positive rate, negative rate and tumor/non-tumor ratio were calculated. Results show positive rate of imaging of tumor was 100%. The most distinct pictures were gained between 4 to 6 h after injection of tracer. T/NT ratios of experimental group were higher than that of control groups (P0.05). RII of OC125 McAb labelled with 99mTc on the nude mice models was sensitive and specific. 16 ovarian neoplasm patients were received RII 6 h after intravenous injected OC125 McAb labelled with 99mTc. Four patients of malignant tumor repeated RII after operation and chemotherapy. The result of RII was accorded perfectly with operation. RII also can find micro recurrence leision of post-operation. The sensitivity and specificity was more excellent than the radioimmunoassay of CA125. RII is useful for definiting character of ovarian tumor, especially for detecting early recurrence leision of post-operation patients." @default.
- W2380694534 created "2016-06-24" @default.
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- W2380694534 date "1999-01-01" @default.
- W2380694534 modified "2023-09-24" @default.
- W2380694534 title "Radioimmunoimaging of (99m)~Tc-OC125 on Experimental Research and Clinical Application of Ovarian Cancer" @default.
- W2380694534 hasPublicationYear "1999" @default.
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