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- W2380698085 abstract "Thymic hormones modulating the maturation of T lymphocytes play veryimportant roles in cell mediated immunity.Preliminary results of the studies on the porcine thymic hormone T_1 receptorwith radioreceptorassay of ~(125)I-thymic hormone T_1 are reported.There are thymic hormone receptors located on the surface of the T lymphooytes,at pH6.0 and 37℃,a maximal specific binding of hormone to lymphocytes can beattained in 60～90 minutes of incubation.With the addition of either insulin,cortison or thyroxin to the assay system,no effect on the binding of thymic hormoneT_1 to receptors could be detected.This shows that the binding is specific.Thymic hormone F_1 another component of the thymic hormone family,differsfrom T_1 in some biochemical properties,but competes with the same receptor;whetherthis fact implies that both affect the same subclasses of T lymphocyte remains to besolved.The binding capacity of thymic hormone T_1 to its receptor is parallel to theactivity of the hormone.T_1 is degraded gradually by trypsin digestion and simultane-ously loses its capacity to combine with the corresponding receptor.Thus the amountof thymic hormone detected by radioreceptorassay may be considered to represent oneparameter of its biological activity.The measurable range of the assay is between10to 1000ng." @default.
- W2380698085 created "2016-06-24" @default.
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- W2380698085 date "1982-01-01" @default.
- W2380698085 modified "2023-09-25" @default.
- W2380698085 title "STUDIES ON THE THYMIC HORMONE RECEPTOR" @default.
- W2380698085 hasPublicationYear "1982" @default.
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